Privacy-Preserving Federated Learning in Healthcare - A Secure AI Framework

Abstract

Federated Learning (FL) has transformed AI applications in healthcare by enabling collaborative model training across multiple institutions while preserving patient data privacy. Despite its advantages, FL remains susceptible to security vulnerabilities, including model inversion attacks, adversarial data poisoning, and communication inefficiencies, necessitating enhanced privacy-preserving mechanisms. In response, this study introduces Privacy-Preserving Federated Learning (PPFL), an advanced FL framework integrating Secure Multi-Party Computation (SMPC), Differential Privacy (DP), and Homomorphic Encryption (HE) to ensure data confidentiality while maintaining computational efficiency. I rigorously evaluate PPFL using Federated Averaging (FedAvg), Secure Aggregation (SecAgg), and Differentially Private Stochastic Gradient Descent (DP-SGD) across real-world healthcare datasets. The results indicate that this approach achieves up to an 85% reduction in model inversion attack success rates, enhances privacy efficiency by 30%, and maintains accuracy retention between 95.2% and 98.3%, significantly improving security without compromising model performance. Furthermore, comparative visual analyses illustrate trade-offs between privacy and accuracy, scalability trends, and computational overhead. This study also explores scalability challenges, computational trade-offs, and real-world deployment considerations in multi-institutional hospital networks, paving the way for secure, scalable, and privacy-preserving AI adoption in healthcare environments.